This study aims to evaluate potential toxic effect of Jatropha curcas leaves methanol extract on laboratory rats as well as determine its\r\nLD50. A total of 80maleWistar rats were used as the experimental animals, 40 for LD50 determination and the other 40 for toxicity\r\nstudy. Based on the pretest that was done in order to establish a range of toxicity, 4 dosages (86.00, 58.00, 46.00, and 34.0 kg/body\r\nweight) were chosen. The rats were randomly assigned into four groups with 10 rats in each group. Rats in groups 1, 2, 3, and 4 were\r\ngiven 0mg/kg, 500mg/kg, 1000mg/kg, and 2000mg/kg body weight of Jatropha curcas extract, respectively, by oral intubation\r\nfor 21 days. Thereafter, clinical signs, change in body weight, toxicity symptoms, and biochemical parameters were obtained.The\r\nLD50 at 95% confidence limits for rats was 46.0mg/kg body weight (44.95ââ?¬â??52.69mg/kg body mass). There was no clinical and\r\nbiochemical signs of toxicity when the extract was administered at 500, 1000, and 2000mg/kg body weight, respectively (P > 0.05).\r\nResults obtained from this study suggest that liver, kidney, and haematological system of rats tolerated methanolic leave extract of\r\nJatropha curcas at a certain concentration.
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